Simulacro de un día de trabajo en un restaurante de habla inglesa. Una experiencia compartida entre el nivel medio y superior

El desempeño laboral y profesional en el mundo actual requiere el desarrollo de la competencia comunicativa en lenguas extranjeras y es necesario desarrollar las cuatro habilidades comunicativas: leer, escribir, hablar y escuchar. Desde esta perspectiva, es un objetivo común conseguir que los estudiantes usen la lengua extranjera en situaciones que se acerquen a la vida real. El presente trabajo se enmarca en la enseñanza de la lengua extranjera desde una perspectiva comunicativa, el aprendizaje basado en tareas, la formación por competencias y el aprendizaje como construcción colectiva. Se realizó una jornada en la que se simuló un almuerzo en un restaurante de habla inglesa. Para ello, los estudiantes de la Tecnicatura en Gestión Gastronómica de la Facultad de Bromatología (UNER) diseñaron un menú, realizaron cálculos para su preparación, y se entrenaron en la atención al público en lengua extranjera. El día de la jornada, elaboraron los platos del menú en tiempo real y actuaron como mozos y anfitriones de un grupo de alumnos de una escuela secundaria, que fueron invitados como comensales. La enseñanza de las lenguas requiere establecer un marco visible y auténtico para su uso, este simulacro de la vida real fue una instancia visible y auténtica de uso comunicativo de la lengua

Targeting the phosphatidylinositol 3-kinase/Akt/mechanistic target of rapamycin signaling pathway in B-lineage acute lymphoblastic leukemia: An update

Despite considerable progress in treatment protocols, B-lineage acute lymphoblastic leukemia (B-ALL) displays a poor prognosis in about 15–20% of pediatric cases and about 60% of adult patients. In addition, life-long irreversible late effects from chemo- and radiation therapy, including secondary malignancies, are a growing problem for leukemia survivors. Targeted therapy holds promising perspectives for cancer treatment as it may be more effective and have fewer side effects than conventional therapies. The phosphatidylinositol 3-phosphate kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling pathway is a key regulatory cascade which controls proliferation, survival and drug-resistance of cancer cells, and it is frequently upregulated in the different subtypes of B-ALL, where it plays important roles in the pathophysiology, maintenance and progression of the disease. Moreover, activation of this signaling cascade portends a poorer prognosis in both pediatric and adult B-ALL patients. Promising preclinical data on PI3K/Akt/mTOR inhibitors have documented their anticancer activity in B-ALL and some of these novel drugs have entered clinical trials as they could lead to a longer event-free survival and reduce therapy-associated toxicity for patients with B-ALL. This review highlights the current status of PI3K/Akt/mTOR inhibitors in B-ALL, with an emphasis on emerging evidence of the superior efficacy of synergistic combinations involving the use of traditional chemotherapeutics or other novel, targeted agents

Staphylococcal scalded skin syndrome in adults with obesity and type 2 diabetes: A case series

: Staphylococcal scalded skin syndrome (SSSS) primarily affects children and rarely adults with immunodepression. We describe two cases of adults diagnosed with SSSS with no additional cause of immunological compromise other than obesity and uncontrolled diabetes. An increased risk of infection should be considered in cases of obesity and diabetes

Aplicación de herramientas de costos en pequeñas empresas vitivinícolas de Mendoza

El trabajo de investigación tiene como objetivo exponer sobre la aplicación de herramientas de gestión de costos en pequeñas empresas vitivinícolas de Mendoza y analizar los efectos que ello provoca en la toma de decisiones. La aplicación de herramientas de gestión de costos permite conocer la estructura de estos y saber cómo gestionar los mismos de manera más eficiente. La organización que se interese en mejorar la calidad a partir de la especialización de la cadena de valor extendida necesitará la definición de unidades de costeo para asignar los costos operativos y estructurales de la organización a sus productos o servicios. La idea de aplicar instrumentos de gestión de costos para el cálculo e información sobre los mismos afecta el diseño de sus sistemas de información por la importancia de aquellos sobre variables claves de los negocios. Cómo resultado del relevamiento, mediante cuestionarios aplicados a pequeñas bodegas de Mendoza, se entiende que la mayoría se encuentra en la fase Cero de implementación de un sistema de información de costos. La fase cero se caracteriza por la utilización de un software enlatado que soluciona aspectos contables y legales, pero no brinda información adecuada sobre costos. Como resultado de lo expuesto anteriormente, es de suma importancia para toda empresa contar con información de costo oportuna y confiable. Es por eso que el presente trabajo, propone alternativas para que las pequeñas bodegas de Mendoza puedan contar con información de Costos, sin necesidad de incurrir en altos costos de tiempo y económicos . .Fil: Alvarez, Yanel Carolina. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Bajik, Adrián. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Bello, Juan Maria. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Vitale, Rubén Maximiliano. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas

Validity of self-reported weight and height by high school students in the city of Cordoba city

Objetivo: Examinar la validez del peso y la estatura declarados respecto de su medición directa, para el diagnóstico de sobrepeso y obesidad en adolescentes escolarizados de la ciudad de Córdoba. Métodos: Se realizó un estudio piloto transversal con 552 adolescentes de 1° a 3° año de tres escuelas secundarias. El peso y la talla se recolectaron mediante un cuestionario autoadministrado y fueron medidos directamente por personal entrenado. Se calcularon diferencias de promedio de peso, talla e índice de masa corporal (IMC=kg/cm2 ) y sensibilidad-especificidad y coeficiente de concordancia (k) para las categorías de diagnóstico. Resultados: El peso declarado promedio fue subestimado respecto del medido; no así la talla. El IMC declarado resultó subestimado en -0,85 kg/cm2 en mujeres y -0,26 kg/cm2 en varones. La sensibilidad-especificidad fue 61%-89% para detectar sobrepeso y 80%-98% para diagnosticar obesidad. Conclusión: El peso y la talla autoinformados produjeron subestimación de la prevalencia de sobrepeso pero no de obesidad.Objective: To examine the validity of self-reported weight and height versus their direct measurement for the diagnosis of overweight and obesity in adolescent students in the city of Cordoba. Methods: A cross-sectional pilot study was carried out with 552 adolescents attending 1st to 3rd year at three high schools. Weight and height were collected through a selfadministered questionnaire and were measured directly by trained staff. We calculated average differences for weight, height and body mass index (BMI = kg/cm2), and sensitivityspecificity and concordance coefficient (k) were analyzed for overweight and obesity diagnosis. Results: Average self-reported weight was underestimated compared to measured weight, but not self-reported height. Declared BMI was underestimated -0.85 kg/cm2 in women and -0.26 kg/cm2 in men. The sensitivity-specificity was 61%-89% to detect overweight, and 80%-98% to diagnose obesity. Conclusion: The self-reported weight and height underestimated the prevalence of overweight but not of obesity.Fil: Vitale, Romina. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Salud Pública; Argentina. Centro Interamericano de Estudios de Seguridad Social; MéxicoFil: Lavin Fueyo, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro Interamericano de Estudios de Seguridad Social; MéxicoFil: Rivera, Carolina. Centro Interamericano de Estudios de Seguridad Social; MéxicoFil: Mamondi, Verónica. Centro Interamericano de Estudios de Seguridad Social; MéxicoFil: Berra, Silvina del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro Interamericano de Estudios de Seguridad Social; Méxic

Negative and positive implications of social networks in bronchial asthma

Bronchial asthma is a disease in which psychological implications play a role in increasing or in reducing the severity of bronchial obstruction. Internet and, in particular, social media are increasingly a part of daily life of both young and adult people, thus allowing virtual relationships with peers sharing similar interests and goals. Although social network users often disclose more about themselves online than they do in person, there might be a risk for adolescents and for sensitive individuals, who can be negatively influenced by an incorrect use. However, although some studies show an increased risk of depression, other observations suggest beneficial effects of social network by enhancing communication, social connection and self-esteem. In addition, social network represent a useful tool in disseminating public health messages

[Thunderstorm and asthma outbreaks during pollen season]

An increasing body of evidence shows the occurrence of asthma epidemics, sometimes also severe, during thunderstorms in the pollen season in various geographical zones. The main hypothesis explaining association between thunderstorms and asthma claims that thunderstorms can concentrate pollen grains at ground level; these grains may then release allergenic particles of respirable size in the atmosphere after their rupture by osmotic shock. During the first 20-30 minutes of a thunderstorm, patients suffering from pollen allergy may inhale a high concentration of the allergenic material dispersed into the atmosphere, which can, in turn, induce asthmatic reactions, often severe. Subjects without asthma symptoms but affected by seasonal rhinitis can also experience an asthma attack. All subjects affected by pollen allergy should be alerted to the danger of being outdoors during a thunderstorm in the pollen season, as such events may be an important cause of severe bronchial obstruction. Considering this background, it is useful to predict thunderstorms during pollen season and, thus, to prevent thunderstorm-related clinical event. However, it is also important to focus on therapy, and it is not sufficient that subjects at risk of asthma follow a correct therapy with bronchodilators, but they also need to inhale corticosteroids, using both in case of emergency

Modulation of Antioxidant Compounds in Fruits of Citrus reticulata Blanco Using Postharvest LED Irradiation

Phlegrean mandarin fruits are already known for health-promoting properties due to the high concentration of phytochemicals in peel, pulp, and seed. Biotic and abiotic factors, including light, may modulate their biosynthesis, metabolism, and accumulation. In this context, light-emitting diodes (LED) have recently been applied to control nutritional traits, ripening process, senescence, fruit shelf-life, and pathogenic microbial spoilage of fruits. This study investigated the effect of the seven-day exposure of Phlegrean mandarin fruits to two LED regimes, white (W) and red–blue (RB), to test the possibility that the storage under specific light wavelengths may be used as green preservation technology that enhances fruit phytochemical properties. To pursue this aim, the antioxidant activity and polyphenolic profile of the pulp and peel of mandarins under W and RB light regimes were evaluated and compared with Control fruits not exposed to LED treatment. Our results indicated that storage under W and RB treatments modulates the antioxidant content in pulp and peel differently. Compared to W, the RB regime increases the ascorbic acid, flavonoid, anthocyanin, and carotenoid concentrations, while the polyphenol profile analysis reveals that the number of important phytochemicals, i.e., quercetin rutinoside, chlorogenic acid, sinensetin, and rutin, are higher under W. The overall data demonstrated that postharvest LED irradiation is a valid tool for modifying fruit phytochemical properties, which also boosts specific bioactive compounds

Treating severe allergic asthma with anti-IgE monoclonal antibody (omalizumab): a review

Increased asthma severity is not only associated with enhanced recurrent hospitalization and mortality but also with higher social costs. Several cases of asthma are atopic in nature, with the trigger for acute asthma attacks and chronic worsening of inflammation being allergens inducing an immune, IgE mediated response. Anti-inflammatory treatments are effective for most of asthma patients, but there are subjects whose disease is incompletely controlled by inhaled or systemic corticosteroids and these patients account for about 50% of the healthcare costs of asthma. Omalizumab is a biological engineered, humanized recombinant monoclonal anti-IgE antibody developed for the treatment of allergic diseases and with clear efficacy in adolescent and adult patients with severe allergic asthma. The anti-IgE antibody inhibits IgE functions blocking free serum IgE and inhibiting their binding to cellular receptors. By reducing serum IgE levels and IgE receptor expression on inflammatory cells in the context of allergic cascade, omalizumab has demonstrated to be a very useful treatment of atopic asthma, improving quality of life of patients with severe persistent allergic asthma that is inadequately controlled by currently available asthma medications. Several trials have demonstrated that this therapy is well tolerated and significantly improves symptoms and disease control, reducing asthma exacerbations and the need to use high dosage of inhaled corticosteroids

Antioxidant Properties of Pulp, Peel and Seeds of Phlegrean Mandarin (Citrus reticulata Blanco) at Different Stages of Fruit Ripening

In this work, we assess the potential of waste products of Phlegrean mandarin (Citrus reticulata Blanco), namely seeds and peel, to be reutilized as a source of bioactive compounds beneficial for the human diet. Starting from the evidence that the by-products of this specific cultivar are the most powerful sources of antioxidants compared to pulp, we have investigated if and how the bioactive compounds in peel and seeds may be affected by fruit ripening. Three stages of fruit ripening have been considered in our study: unripe fruits = UF, semi-ripe fruits = SRF, ripe fruits = RF. The overall results indicated that RF showed the highest concentration of antioxidants. Among fruit components, peel was the richest in total antioxidant capacity, total polyphenol content, total flavonoids, total chlorophylls and carotenoids, while seeds exhibited the highest concentration of total condensed tannins and ascorbic acid. The liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay indicates the occurrence, in peel extracts, of 28 phenolic compounds, mainly flavonoids (FLs); in seeds, 34 derivatives were present in the first stage (UF), which diminish to 24 during the ripening process. Our data indicated that the content of phytochemicals in citrus strongly varies among the fruit components and depends on the ripening stage. The higher antioxidant activity of peel and seeds, especially in RF, encourage a potential use of by-products of this specific citrus cultivar for industrial or pharmacological applications. However, to maximize the occurrence of desired bioactive compounds, it is important also to consider the ripening stage at which fruits must be collected